- Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi
- Vol: 25 Issue: 2
- Novel perylene diimide based antiproliferative chromophores
Novel perylene diimide based antiproliferative chromophores
Authors : Furkan Ozcil, Hatice Yildirim, Merve Karaman, Funda Yükrük
Pages : 761-769
Doi:10.25092/baunfbed.1277996
View : 17 | Download : 12
Publication Date : 2023-07-07
Article Type : Research Article
Abstract :The primary objective of the work was to monitor the antiproliferative activity of two newly synthesized and described perylene diimides. The MTT test was used to investigate the antiproliferative effect against PC3 the prostat cancer cell line, Panc1 pancreatic cancer cell line, Saos2 osteosarcoma cell line, Hep3B hepatoma cell line and HUVEC non-cancerous human umbilical vein endothelial cells. To PC3, Panc1, and Saos 2 cells, both compounds were found to be considerably cytotoxic; however, a comparable impact was not seen in Hep3B cells. Compound 2 had the lowest IC50 value of 40,88 µg/ml and significantly inhibited PC3 cell proliferation when compared to other cell lines.Keywords : Perilen diimid, Antiproliferatif aktivite, Sitotoksisite