- Balıkesir Sağlık Bilimleri Dergisi
- Vol: 12 Issue: 1
- Clinicopatological Examination of Waldeyer’s Ring Lymphomas: A Cross-Sectional Study in Turkey
Clinicopatological Examination of Waldeyer’s Ring Lymphomas: A Cross-Sectional Study in Turkey
Authors : Çiğdem Özdemir, Nilhan Eryeğen, Filiz Yavaşoğlu, Mehmet Olgun Ak, Selçuk Kuzu, Mustafa Duran, Burcu Belen Aydoğmuş, Büşra Çetinkaya, Abdulkadir Bucak, Yiğit Şenol
Pages : 81-88
Doi:10.53424/balikesirsbd.1241429
View : 13 | Download : 4
Publication Date : 2023-03-15
Article Type : Research
Abstract :Objective: Waldeyer\'s ring (WR) is the second most common site of extranodal lymphomas. Its clinical course may resemble those of nodal lymphomas. We evaluated the histopathological and clinical findings, Epstein-Barr virus (EBV) presence, and overall survival of WR lymphomas diagnosed in our department. Materials and Methods: Retrospectively, 32 patients were included. The demographic and clinical data of the patients and lymphoma types, the presence of EBV [EBV early RNAs (EBER)] by chromogenic in-situ hybridization (CISH) method were examined. Kaplan-Meier analysis was used for the survival rate. A P value less than 0.05 was considered statistically significant. Results: 23 of 32 cases were male. The mean age was 57.97±16.15 years. The preliminary clinical diagnosis was carcinoma in 46.9% of the cases. Tonsil and nasopharynx had equal proportions as lymphoma origin. Only 3 (9.4%) cases are classic Hodgkin lymphoma (CHL). 16 cases (50.0%) were diffuse large B-cell lymphoma (DLBCL). EBER was detected only in tonsillar CHL cases. The survival of patients with nasopharyngeal lymphoma was shorter than those of tonsillar origin (p=0.037). Conclusion: DLBCL is the most common lymphoma type of this localization. EBER positivity has been detected only in CHL. Survival is lower in lymphomas originating from the nasopharynxKeywords : Non-Hodgkin Lenfoma, Waldeyer Halkası, Nazofarenks, Tonsil, EBER