- Communications Faculty of Sciences University Ankara Series B Chemistry and Chemical Engineering
- Vol: 31
- ASYMMETRIC SYNTHESIS İN A REFORMATZKY REACTION PREPARATION OF OPTICALLY ACTIVE p-HYDROXY ACIDS
ASYMMETRIC SYNTHESIS İN A REFORMATZKY REACTION PREPARATION OF OPTICALLY ACTIVE p-HYDROXY ACIDS
Authors : H. H. Zoorob
Pages : 0-0
Doi:10.1501/Commub_0000000265
View : 7 | Download : 6
Publication Date : 1985-01-01
Article Type : Research
Abstract :Reaction of benzaldehyde with optically active bromoacetic ester derivative I in a Refor* matzky reaction gives, after hydrolysis of the resulting ester, laevorotatory B-hydroxy-Bphenyl phenyl-propionic acid. Moreover, reaction of ethyi bromoacetate with acetophenone in the pre¬sence of zinc and 1,2:5,6-di-Odsopropylideno-a-D-glucofuranose (II) is accompanied by partial asymmetric synthesis as is shownby hydrolysis of the resulting ester to laevorotatory B-hydroxy -B-phenylbutyric acid.Keywords : ASYMMETRIC, REFORMATZKY REACTION, p-HYDROXY ACIDS