- Communications Faculty of Sciences University Ankara Series A2-A3 Physical and Engineering
- Vol: 61 Issue: 1
- SYNAPTIC TRANSMISSION: A MODEL ON THE FORMATION OF END-PLATE POTENTIAL AND A STUDY ON SIMULATION
SYNAPTIC TRANSMISSION: A MODEL ON THE FORMATION OF END-PLATE POTENTIAL AND A STUDY ON SIMULATION
Authors : Levent Özbek, Çağrı Temucin, Bülent Cengiz, Fikri Özturk
Pages : 24-32
Doi:10.33769/aupse.467095
View : 15 | Download : 6
Publication Date : 2019-06-30
Article Type : Research
Abstract :In this study, the emergences of postsynaptic action potentials are investigated using simulation study which is depended on the statistical model of acetylcholine (Ach) quantal release theory at motor end-plate. It is supposed that the end-plate potentials (EPP) are sum of miniature end-plate potentials (MEPP) which are released as quantal and random in number (N). By the hypothesis that N number has a Poisson and MEPPs have a Gaussian distribution, EPPs are obtained by simulating distributions parameters. Our study suggests that the simulation of the EPPs are a convenient tool in understanding both physiological process of synaptic transmission and pathological process of neuromuscular junction.Keywords : Synaptic transmission, EPP, MEPP