- Acta Medica Nicomedia
- Vol: 6 Issue: 2
- Association Between Left Atrial Appendage Thrombus Formation and Monocyte/HDL Ratio in Patients with...
Association Between Left Atrial Appendage Thrombus Formation and Monocyte/HDL Ratio in Patients with Acute Ischemic Stroke
Authors : Süha Çetin, Mustafa Gökhan Vural
Pages : 248-254
View : 24 | Download : 32
Publication Date : 2023-06-30
Article Type : Research Article
Abstract :Objective: There is an apparent link between thrombus formation and inflammation. Monocyte/HDL ratio (MHR) has been determined as an inflammatory marker and associated with many cardiovascular disorders like coronary artery disease, acute coronary stent thrombus, coronary thrombus burden and atrial fibrillation (AF). The purpose of this study was to elucidate the association between MHR and left atrial appendage thrombus formation (AATF) in patients with acute ischemic stroke. Methods: A total of 69 patients with the diagnosis of acute ischemic stroke were retrospectively enrolled in the study. Demographic, clinical and echocardiographic data were collected retrospectively from the patients’ records. MHR and neutrophil/lymphocyte ratio (NLR) were calculated from the present laboratory data. Results: There was a significant positive correlation between MHR and NLR (r=0.6; p<0.001). Thirteen patients had a left AATF (11 male; 64±14.5 years); 14 patients had spontaneous echo contrast (SEC) stage 3 or 4 (11 male; 62.3±9.7 years) and 42 patients (29 male; 61.0±11.1 years) did not have left AATF or SEC. There was no difference between the 3 groups in terms of baseline demographic or clinical findings except AF (p<0.001). Further, monocytes were significantly lower in the thrombus negative group compared to other groups (p<0.001). MHR was different in all three groups (p<0.001). This parameter was significantly increased in patients with left AATF and SEC finding. Conclusion: Our study showed that an increased MHR is associated with left AATF.Keywords : Monosit/HDL oranı, sol atrial appendaj, atriyal fibrillasonyon