- Acta Medica Nicomedia
- Vol: 6 Issue: 1
- Effects of Long-Acting Methylphenidate Formulations and Atomoxetine on Cardiac Functions in Children...
Effects of Long-Acting Methylphenidate Formulations and Atomoxetine on Cardiac Functions in Children with Attention Deficit And Hyperactivity Disorder
Authors : Ajda Mutlu Mihçioğlu, Tayfun Kara
Pages : 98-106
View : 11 | Download : 7
Publication Date : 2023-02-28
Article Type : Research
Abstract :Objectives: Methylphenidate (MPH) and Atomoxetine (ATX) are most commonly prescribed for the treatment of Attention Deficit And Hyperactivity Disorder (ADHD). Despite their widespread use, there are concerns about their cardiovascular safety. In this study, we aimed to investigate the effects of ADHD medications on cardiac functions. Methods: Forty-six children with ADHD disorder using osmotic-release oral system methylphenidate (OROS-MPH), 46 using extended-release methylphenidate (ER-MPH), and 46 using ATX for at least six months were included in the patient groups. 46 children with normal cardiac findings were included as the control group. All participants were evaluated using a sociodemographic information form, physical examination, 12-channel electrocardiography (ECG), transthoracic 2D echocardiography, Doppler echocardiography, and tissue Doppler imaging (TDI). Results: Statistically significant differences were observed in terms of A wave velocity (p=0,002), E/A (p<0,001), and E’ septal (p=0,002) between the groups. Children using ATX had higher A wave velocity than OROS-MPH users and controls (p<0.001, p=0.007, respectively) and lower E/A than OROS-MPH users and controls (p<0.001, for both). Children using ER-MPH and ATX had lower E’ septal values compared to the control group (p<0.001, p=0.002, respectively). Heart rate is higher in ATX users than in the control group (p=0,002). Systolic blood pressure was lower in the ER-MPH and ATX group compared to the control group (p=0.001, for both). Conclusion: ATX medication exhibited impaired myocardial relaxation findings more than long acting-MPH medications. ER-MPH medication stated negative findings in diastolic cardiac functions more than OROS-MPH. As a result ADHD medications can produce negative effects on cardiac functions.Keywords : metilfenidat, atomoksetin, doku Doppler görüntüleme, dikkat eksikliği ve hiperaktivite bozukluğu