- Turkish Journal of Kinesiology
- Cilt: 9 Sayı: 3
- Genetic factors and anterior cruciate ligament injury risk in professional football players: COL3A1 ...
Genetic factors and anterior cruciate ligament injury risk in professional football players: COL3A1 (rs1800255) and COL5A1 (rs12722) polymorphisms
Authors : Gökhan Ipekoğlu, Halil Ibrahim Çakir, Nihan Bozkurt, Alpay Bülbül, Sadegul Tuncer Savkin, Necdet Apaydin
Pages : 195-203
Doi:10.31459/turkjkin.1329105
View : 51 | Download : 33
Publication Date : 2023-09-30
Article Type : Research
Abstract :This study was conducted to investigate the genotype and allele distributions of COL3A1 (rs1800255) and COL5A1 (rs12722) polymorphisms of professional footballers who have suffered at least 2 anterior cruciate ligament (ACL) injuries non-contact and professional footballers who have never had a ligament injury. The research group consists of 108 professional men\'s football players ACL group (n=45), Control group (n=63) with at least 10 years of football background. The results ACL and control groups were compared by Chi-square or Fischer’s exact test. There were no significant differences noted neither in terms of genotype distribution of COL3A1 (rs1800255) nor A-allele frequency distribution between control (CON) and ACL group. A highly significant difference in the allele distribution was noted for COL5A1 (rs12722) with the T-allele significantly less frequent in CON than ACL. The TT genotype compared to the C alleles (TC + CC) showed significant relationship between the TT genotype and ACL injury potential in the dominant model. However, it was not showing significance in the recessive (TT + TC vs. CC). In conclusion, it can be said that professional football players who have the COL5A1 rs12722 C allele have about 2 times lower risk of anterior cruciate ligament injury. In the COL3A1 rs1800255 polymorphism, there is no relationship between the groups in terms of genotypes and allele distribution.Keywords : ACL, COL3A1, COL5A1, gene, football, polymorphism