- Turkish Journal of Analytical Chemistry
- Cilt: 5 Sayı: 2
- Molecular docking study on acetylcholinesterase and urease enzyme inhibition effects of Amygdalin
Molecular docking study on acetylcholinesterase and urease enzyme inhibition effects of Amygdalin
Authors : Zehra Can, Yakup Kara, Halil Ibrahim Güler, Ceren Birinci, Sevgi Kolayli
Pages : 143-150
Doi:10.51435/turkjac.1390923
View : 51 | Download : 47
Publication Date : 2023-12-29
Article Type : Research
Abstract :This study investigated that the acetylcholinesterase, urease enzyme inhibition and these enzymes molecular docking as well as antioxidant activity of commercially available amygdalin. While Amygdalin displayed effect anti-urease activity compared to acetohydroxamic acid but, anti-acetylcholine esterase activity a little ineffective compared to donepezil. The molecular docking was performed in order to check binding interactions between the amygdalin and the enzymes. DPPH and FRAP assays were preferred to determine the antioxidant activity. The antioxidant activity (3.39±0.33 µmol Fe2SO47H2O /g, SC50 18.74±0.72 mg/mL using the FRAP and DPPH assays, respectively. Amygdalin\'s in vitro and in vivo studies are needed for demonstrated that is a therapeutic agent for the treatment of various diseases.Keywords : Acetylcholinesterase, Urease, Molecular Docking, Antioxidant Activity, Amygdalin