- Turkish Journal of Medical Sciences
- Vol: 50 Issue: 4
- Does capsaicin have therapeutic benefits in human colon adenocarcinoma? Selection of the most reliab...
Does capsaicin have therapeutic benefits in human colon adenocarcinoma? Selection of the most reliable dose via AgNOR
Authors : Mustafa Nisari, Recep Eröz
Pages : 1076-1081
Doi:10.3906/sag-2003-251
View : 15 | Download : 0
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Background/aim: To determine the effect of different doses of capsaicin on AgNOR protein synthesis in human colon adenocarcinoma derivate from colon cancer Caco-2 cell . Materials and methods: In this experimental study, after the cultured of Caco-2 cell line, the cells are divided into 4 groups as control and different capsaicin exposed doses 25uµ, 50uµ, and 75uµ . Mean AgNOR number and total AgNOR area/nuclear area TAA/NA were calculated. Results: A significant differences were detected between control and capsaicin 50uµ P = 0.001 , between control and capsaicin 75uµ P = 0.000 , between capsaicin 25uµ and capsaicin 50uµ P = 0.001 and between capsaicin 25uµ and capsaicin 75uµ P = 0.000 for TAA/NA. Also, there were significant differences between control and capsaicin 50uµ P = 0.001 , between control and capsaicin 75uµ P = 0.000 , between capsaicin 25uµ and capsaicin 50uµ P = 0.000 and between capsaicin 25uµ and capsaicin 75uµ P = 0.000 for mean AgNOR number. Conclusion: A certain amount of capsaicin has a protective effect against colon adenocarcinoma and the dose concentrations are important for the most reliable treatment.Keywords : AgNOR, capsaicin, human colon adenocarcinoma, rDNA, caco-2 cell line