- Turkish Journal of Medical Sciences
- Vol: 50 Issue: 4
- Prospective evaluation of vascular changes in acute respiratory infections in children with cystic f...
Prospective evaluation of vascular changes in acute respiratory infections in children with cystic fibrosis
Authors : Gökçen Kartal Öztürk, Aykut Eşki, Figen Çelebi Çelik, Seçil Conkar, Figen Gülen, Esen Demir, Ahmet Keskinoğlu
Pages : 1007-1014
Doi:10.3906/sag-2002-61
View : 14 | Download : 0
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Background/aim: Acute exacerbations and chronic inflammation are risk factors for cardiovascular disease CVD in cystic fibrosis CF patients. The aim of this study was to investigate the effects of acute exacerbation therapy on arterial stiffness in children with CF. Materials and methods: Augmentation index Aix and pulse wave velocity PWV were measured before and after treatment and 1 month after the end of treatment in patients with acute exacerbation. The relationship between hemodynamic measurements and c-reactive protein CRP and pulmonary function tests PFTs was investigated. Results: Measurements before and after treatment were evaluated in 27 patients and were repeated in 21 patients who were clinically stable 1 month following acute exacerbation. There was a significant decrease in CRP and an increase in spirometry parameters after treatment. While no significant difference was found between PWV P = 0.33 , a significant difference for Aix before 41.95 ± 12.96% and after 30.95 ± 11.47% treatment and before treatment and stable clinical condition 34.19 ± 14.36% was obtained P =0.00, and P =0.01, respectively . No significant difference in heart rate and other hemodynamic measurements was found. Pretreatment Aix is associated with poor clinical condition PFTs, BMI, and clinical score and systemic inflammation CRP PKeywords : Cystic fibrosis, arterial stiffness, pulse wave velocity analysis, augmentation index, pulmonary exacerbation