- Turkish Journal of Medical Sciences
- Vol: 50 Issue: 4
- Evaluation of the effects of ß1-selective beta-blockers on bone mineral density and fracture risk in...
Evaluation of the effects of ß1-selective beta-blockers on bone mineral density and fracture risk in postmenopausal women
Authors : Betül Yavuz Keleş, Meltem Vural, Burcu Önder, Kadriye Öneş
Pages : 994-998
Doi:10.3906/sag-1909-187
View : 16 | Download : 0
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Background/aim: ß1-selective beta-blockers BBs are sympatholytic agents, and discerning their effects on bone health would be of great importance. This study aimed to investigate the influence of ß1-selective BBs on bone mineral density BMD and fracture risk. Materials and methods: This study included postmenopausal women who used ß1-selective BBs BB group and control group. Sociodemographic characteristics, BMD and previous fragility fractures were recorded. Additionally, the 10-year probability of a major osteoporotic and hip fracture was calculated using the fracture risk assessment tool FRAX . Results: A total of 60 participants were included in the study. L1-4 and L2-4 BMD values were significantly higher in BB group than control group P = 0.015 and P = 0.025, respectively . Moreover, T-scores of lumbar and femur total were significantly higher in the BB group. Two patients in BB and 6 patients in control group had previous fragility fracture. No statistically significant intergroup difference was noted regarding FRAX. Conclusion: Based on our results, ß1-selective BB usage was associated with higher BMD at the lumbar region in postmenopausal women.Keywords : Adrenergic beta-antagonists, postmenopause, bone mineral density