- Turkish Journal of Medical Sciences
- Vol: 50 Special Issue
- COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs
COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs
Authors : Abdurrahman Tufan, Aslıhan Avanoğlu Güler, Marco Matucci-cerinic
Pages : 620-632
Doi:10.3906/sag-2004-168
View : 16 | Download : 2
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :In the Wuhan Province of China, in December 2019, the novel coronavirus 2019 COVID-19 has caused a severe involvement of the lower respiratory tract leading to an acute respiratory syndrome. Subsequently, coronavirus 2 SARS-CoV-2 provoked a pandemic which is considered a life-threatening disease. The SARS-CoV-2, a family member of betacoronaviruses, possesses singlestranded positive-sense RNA with typical structural proteins, involving the envelope, membrane, nucleocapsid and spike proteins that are responsible for the viral infectivity, and nonstructural proteins. The effectual host immune response including innate and adaptive immunity against SARS-Cov-2 seems crucial to control and resolve the viral infection. However, the severity and outcome of the COVID-19 might be associated with the excessive production of proinflammatory cytokines "cytokine storm" leading to an acute respiratory distress syndrome. Regretfully, the exact pathophysiology and treatment, especially for the severe COVID-19, is still uncertain. The results of preliminary studies have shown that immune-modulatory or immune-suppressive treatments such as hydroxychloroquine, interleukin IL -6 and IL-1 antagonists, commonly used in rheumatology, might be considered as treatment choices for COVID-19, particularly in severe disease. In this review, to gain better information about appropriate anti-inflammatory treatments, mostly used in rheumatology for COVID-19, we have focused the attention on the structural features of SARS-CoV-2, the host immune response against SARS-CoV-2 and its association with the cytokine storm.Keywords : COVID-19, inflammation, cytokine storm, antiinflammatory, treatment, rheumatology