- Turkish Journal of Medical Sciences
- Vol: 50 Issue: 1
- Carbapenem-resistant Klebsiella pneumonia infection outbreak in a tertiary urology clinic: analysis ...
Carbapenem-resistant Klebsiella pneumonia infection outbreak in a tertiary urology clinic: analysis of influencing factors with a controlled trial
Authors : Fuat Kizilay, Bayram Aliyev, Adnan Şimşir, Mustafa Serdar Kalemci, Timur Köse, Meltem Taşbakan, Hüsnü Pullukçu
Pages : 239-247
Doi:10.3906/sag-1909-46
View : 15 | Download : 3
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Background/aim: Carbapenem-resistant Klebsiella pneumoniae CR-KP infections encountered in urology patients differentiate from infections caused by other factors, both in respect to prophylaxis and treatment stage, and require a special approach. We aimed to analyse the predisposing factors and the antibiotherapies for CR-KP infection outbreak in a tertiary urology clinic.Materials and methods: There were 75 patients in the CR-KP positive group Group I and 146 patients in the CR-KP negative group Group II . Analysis of the predisposing factors for CR-KP infection and comparison of the reinfection rate and the antibiotherapies in the 2 groups were the endpoints.Results: In the first group, age, comorbidity, previous antibiotic use, and nephrostomy tube rates were higher P = 0.015, P = 0.001, P = 0.004, and P < 0.001, respectively . In the second group, open urological surgery rate, and the proportion of patients presenting with flank pain, lower urinary tract symptoms, and haematuria were higher P = 0.029, P < 0.001, P < 0.001, and P = 0.007 . In the first group, the proportion of patients treated with transurethral bladder tumour resection was higher, whereas, percutaneous nephrolithotomy was higher in the second group P = 0.045 for both . While hospitalization and Foley catheterization duration were longer in the first group P < 0.001 for both , double J stent and nephrostomy duration were longer in the second group P < 0.001 and P = 0.005 . Mean leukocyte count at admission was higher in the first group P < 0.001 .Conclusion: Advanced age, comorbidities, previous antibiotic use, and prolonged Foley catheterization duration are predisposing factors for this infection in the urology department. Two-week administration of combination antibiotic regimens containing carbapenem were effective for the treatment of this infection.Keywords : carbapenem-resistant Klebsiella pneumonia, antibiotic resistance, urological infection, urological surgery