- Turkish Journal of Medical Sciences
- Vol: 50 Issue: 1
- Thiol/disulfide homeostasis and ischemia modified albumin levels in autoimmune gastritis and their r...
Thiol/disulfide homeostasis and ischemia modified albumin levels in autoimmune gastritis and their relations with gastric emptying
Authors : Emra Asfuroğlu Kalkan, Serap Boz, Özcan Erel, Salim Neşelioğlu, Çağdaş Kalkan, Arif Irfan Soykan
Pages : 163-170
Doi:10.3906/sag-1902-17
View : 18 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Background/aim: Autoimmune gastritis is an autoimmune and inflammatory disorder. The aim of this study is to examine dynamic thiol/disulfide homeostasis and ischemia modified albumin levels, and to analyze the association between thiol/disulfide homeostasis and gastric emptying time in autoimmune gastritis. Materials and methods: Thiol/disulfide homeostasis tests and ischemia modified albumin levels were determined in 50 autoimmune gastritis patients and 53 healthy subjects. Patients with delayed and normal gastric emptying were compared by thiol/disulfide homeostasis tests. Results: The results showed that native thiol μmol/L , total thiol μmol/L , and native thiol/total thiol ratio % of the patients with autoimmune gastritis decreased compared to the control group 177.7 ± 34.18 vs. 245.25 ± 33.83, P = 0.001, 227.25 ± 36.78 vs. 284.20 ± 27.19, P = 0.03, and 8.84 ± 1.1 vs. 7.74% ± 1.3%, P = 0.001 . In addition, native thiol μmol/L , total thiol μmol/L , and native thiol/total thiol ratio % were found to be lower in patients with delayed gastric emptying 198.65 ± 24.27 vs. 167.12 ± 20.51, 241.81 ± 27.14 vs. 213.92 ± 26.35, 8.34 ± 1.29 vs. 7.20 ± 1.83, P = 0.001 . Disulfide level, disulfide/native thiol, disulfide/total thiol P = 0.001 ratios, and ischemia modified albumin levels ABSU, 0.71 ± 0.08 vs. 0.83 ± 0.07 were found to be higher in autoimmune gastritis patients with delayed gastric emptying P = 0.001 . Conclusion: The results showed that thiol/disulfide homeostasis in patients with autoimmune gastritis caused an increase in ischemia modified albumin and disulfide whereas a decrease in thiols. An altered thiol/disulfide balance was also observed in patients with delayed gastric emptying. These results suggest that the oxidative process is involved in patients with autoimmune gastritis.Keywords : Autoimmune gastritis, thiol, disulfide, gastric emptying, oxidative stress