- Turkish Journal of Medical Sciences
- Vol: 50 Issue: 2
- Correlation of serum fatty acid binding protein-4 and interleukin-6 with airflow limitation and qual...
Correlation of serum fatty acid binding protein-4 and interleukin-6 with airflow limitation and quality of life in stable and acute exacerbation of COPD
Authors : Mohammad Reza Aslani, Zeynab Ghazaei, Hassan Ghobadi
Pages : 337-345
Doi:10.3906/sag-1909-9
View : 9 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Background/aim: The serum fatty acid binding protein 4 FABP-4 level increases in chronic inflammatory diseases. The present study aimed to examine serum FABP-4 and interleukin IL -6 levels in patients with stable and acute exacerbation of chronic obstructive pulmonary disease COPD and the correlation of these markers with airflow limitation. Materials and methods: We measured serum FABP-4 and IL-6 levels in 60 COPD patients [30 stable COPD SCOPD , and 30 acute exacerbation of COPD AECOPD ], and 30 healthy subjects and compared them with airflow limitation according to the COPD stage in the Global Initiative for Chronic Obstructive Pulmonary Disease GOLD criteria, peripheral O2 saturation SpO2 , and COPD Assessment Test CAT score. We also tested the association between serum FABP-4 levels and some characteristics of study parameters. Results: Both serum FABP-4 and IL-6 levels increased with increasing severity of GOLD grades in SCOPD P < 0.01 for both and AECOPD groups P < 0.001 and P < 0.01, respectively . It also increased in patients with AECOPD group compared with SCOPD group in GOLD grades I-II P < 0.01 and GOLD grades III-IV P < 0.05 . In addition, there was a significant positive correlation between serum FABP-4 level with IL-6, CAT score, and smoking history and inversely with FEV1 and SpO2 . Conclusion: The study revealed that serum FABP-4 level was elevated with increasing GOLD grades in COPD patients, markedly in acute exacerbation phase. The increase was associated with elevated serum levels of IL-6 and severity of hypoxia. Thus, it seems that FABP-4 may be involved in the pathogenesis of COPD.Keywords : Chronic obstructive pulmonary disease, fatty acid binding protein 4, interleukin-6, airflow limitation