- Turkish Journal of Medical Sciences
- Vol: 49 Issue: 5
- IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms in patients with chronic rhinosinusitis wi...
IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms in patients with chronic rhinosinusitis with sinonasal polyposis
Authors : Gökhan Kuran, Hüseyin Aslan, Süheyl Haytoğlu, Özge Özalp Yüreğir, Sevcan Tuğ Bozdoğan
Pages : 1411-1417
View : 16 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Background/aim: Sinonasal polyposis is a complex chronic disease displaying contributions from multiple genetic and environmental factors. In this study, we analyzed possible genetic factors that increase susceptibility to this widespread inflammatory disease. Materials and methods: A total of 176 adult patients, including 78 patients with sinonasal polyposis and 98 healthy controls, were analyzed for IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms using polymerase chain reaction and enzyme restriction.Results: IL-1RN and IL-4 VNTR polymorphisms were notably associated with sinonasal polyposis (P = 0.0001 and P = 0.036, respectively); however, regarding the IL-2(-330) gene polymorphism, no significant difference was shown between the patient and control groups (P = 0.235). Conclusions: Our study indicates that the RN2 allele of IL-1RN and the RP1 allele of IL-4 might be risk factors for developing sinonasal polyposis.Keywords : Nasal polyposis, IL-1RN VNTR, IL-2(-330), IL-4 VNTR, gene polymorphism