- Turkish Journal of Medical Sciences
- Vol: 49 Issue: 4
- Risk factors for bacteremia in children with febrile neutropenia
Risk factors for bacteremia in children with febrile neutropenia
Authors : Soner Sertan Kara, Hasan Tezer, Meltem Polat, Burcu Ceylan Cura Yayla, Tuğba Bedir Demirdağ, Arzu Okur, Ali Fettah, Saliha Kanik Yüksek, Anil Tapisiz, Zuhre Kaya, Namik Özbek, Idil Yenicesu, Hüsniye Neşe Yarali, Ülker Koçak
Pages : 1198-1205
View : 15 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Background/aim: Bacteremia remains an important cause of morbidity and mortality during febrile neutropenia (FN) episodes. We aimed to define the risk factors for bacteremia in febrile neutropenic children with hemato-oncological malignancies. Materials and methods: The records of 150 patients aged ?18 years who developed FN in hematology and oncology clinics were retrospectively evaluated. Patients with bacteremia were compared to patients with negative blood cultures.Results: The mean age of the patients was 7.5 ± 4.8 years. Leukemia was more prevalent than solid tumors (61.3% vs. 38.7%). Bacteremia was present in 23.3% of the patients. Coagulase-negative staphylococci were the most frequently isolated microorganism. Leukopenia, severe neutropenia, positive peripheral blood and central line cultures during the previous 3 months, presence of a central line, previous FN episode(s), hypotension, tachycardia, and tachypnea were found to be risk factors for bacteremia. Positive central line cultures during the previous 3 months and presence of previous FN episode(s) were shown to increase bacteremia risk by 2.4-fold and 2.5-fold, respectively.Conclusion: Presence of a bacterial growth in central line cultures during the previous 3 months and presence of any previous FN episode(s) were shown to increase bacteremia risk by 2.4-fold and 2.5-fold, respectively. These factors can predict bacteremia in children with FN.Keywords : Bacteremia, children, febrile neutropenia, risk factor