- Turkish Journal of Medical Sciences
- Vol: 49 Issue: 1
- The neutrophil-lymphocyte ratio and its relationship with insulin resistance in obesity
The neutrophil-lymphocyte ratio and its relationship with insulin resistance in obesity
Authors : Serdar KARAKAYA, Mustafa ALTAY, Fatma Kaplan EFE, İbrahim KARADAĞ, Oktay ÜNSAL, Oktay BULUR, MURAT ESER, Derun Taner ERTUĞRUL
Pages : 245-248
View : 13 | Download : 2
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :In this study, our aim was to investigate the neutrophil/lymphocyte (N/L) ratio, variations in leukocytes and leukocyte subtypes, and the relationship between N/L ratio and insulin resistance (IR) in obesity.Materials and methods: Ninety-six patients and 40 healthy controls were included in this study. Patients' blood glucose levels, insulin levels, and hemogram parameters upon 8 h of fasting were determined. Body mass index (BMI) and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) values were calculated.Results: Neutrophil numbers were found to be higher among obese patients with IR than among non-IR obese patients. The N/L ratio was, moreover, found to be higher among obese patients with IR when compared to non-IR obese patients. A positive correlation was found between insulin resistance and both neutrophil and WBC counts. Positive correlations were also found between insulin levels and the N/L ratio, WBC counts, and neutrophil counts.Conclusion: In our study, leukocyte numbers and subtypes were determined to be higher among obese individuals than among healthy individuals. The N/L ratio was increased significantly only among obese patients with IR. Further studies are needed in order to better demonstrate the relationship between the N/L ratio and IR/inflammation.Keywords : Neutrophil-lymphocyte ratio, obesity, insulin resistance