- Turkish Journal of Medical Sciences
- Vol: 49 Issue: 1
- Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease
Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease
Authors : Gül Sema Yildiran Keskin, Özant Helvaci, Çağri Yayla, Özge Tuğçe Paşaoğlu, Çağlar Keskin, Selim Turgay Arinsoy, Ülver Derici
Pages : 139-146
View : 17 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease. Materials and methods: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery. Results: YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = -0.674 and r = -0.471, respectively). Conclusion: This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements.Keywords : YKL-40, CKD, hemodialysis, atherosclerosis, endothelial dysfunction