- Turkish Journal of Medical Sciences
- Vol: 48 Issue: 3
- Role of hepcidin in the diagnosis of sepsis and septic shock in children
Role of hepcidin in the diagnosis of sepsis and septic shock in children
Authors : Osman YEŞİLBAŞ, Esra ŞEVKETOĞLU, Burcu Bursal DURAMAZ, Hasan Serdar KIHTIR, Asuman GEDİKBAŞI, Mey Talip PETMEZCİ, Canan BAYDEMİR
Pages : 517-524
View : 16 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Background/aim: The purpose of this study is to compare the diagnostic value of hepcidin level with the white blood cell (WBC), C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels in pediatric sepsis and septic shock. Materials and methods: A cohort of 89 individuals were divided into four groups: a healthy control group (HCG, n = 28), pediatric intensive care unit control group (PICUCG, n = 17), sepsis group (SG, n = 23), and septic shock group (SSG, n = 21). WBC, CRP, PCT, IL-6, and hepcidin levels were studied in the PICUCG, SG, and SSG, while hepcidin and IL-6 levels were studied in the HCG. Results: In distinguishing the SG and SSG from the HCG, hepcidin sensitivity and specificity were found to be 100%. Distinguishing between the PICUCG and the SG, hepcidin sensitivity was calculated as 95.6% and specificity was calculated as 100%. The sensitivity of WBC, CRP, and PCT was lower than that of hepcidin, but the sensitivity of IL-6 was higher than that of hepcidin. While the specificity of PCT and IL-6 was the same as hepcidin, the specificity of WBC and CRP was lower than that of hepcidin. Conclusion: Hepcidin is a more reliable indicator than WBC and CRP levels in distinguishing children with sepsis and septic shock from healthy children and nonseptic pediatric ICU patients.Keywords : C-reactive protein, hepcidin, interleukin-6, procalcitonin, sepsis, septic shock