- Turkish Journal of Medical Sciences
- Vol: 46 Issue: 1
- The relation between serum cathepsin D level and carotid intima-media thickness in nondiabetic hyper...
The relation between serum cathepsin D level and carotid intima-media thickness in nondiabetic hypertensive patients
Authors : Nihal Özkayar, Fatma Akyel, Ayşe Nurdan Barça, Serhan Vahit Pişkinpaşa, Turan Turhan, Ihsan Ateş, Fatih Dede
Pages : 13-17
View : 15 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Background/aim: We aimed to investigate the relation between carotid intima-media thickness (CIMT) and serum cathepsin D level in hypertensive patients. Materials and methods: This was a cross-sectional study of 74 hypertensive patients (22 males and 52 females, with a mean age of 51.86 ± 11.75 years). Serum levels of cathepsin D were measured with an enzyme-linked immunosorbent assay. CIMT measurements were taken from 3 different points: right and left common carotid arteries, bifurcation, and the first 2 cm of the internal carotid artery. Mean CIMT was calculated by averaging the measurements taken 3 times from each carotid artery. Results: Mean CIMT value was 0.76 ± 0.15 mm, and median cathepsin D level was 190.3 (12.8-2681.3) ng/mL. A marked positive correlation was found between cathepsin D levels and CIMT (r = 0.331, P = 0.04). In multivariate linear regression analysis, cathepsin D, albumin levels, and the duration of hypertension were significant predictors of CIMT (P = 0.017, P = 0.008, and P = 0.043, respectively). Conclusions: Increased serum cathepsin D level was found to be associated with CIMT in nondiabetic hypertensive patients.Keywords : Atherosclerosis, cathepsin D, carotid intima-media thickness, hypertension