- Turkish Journal of Medical Sciences
- Vol: 45 Issue: 5
- Age-related macular degeneration and Alzheimer disease
Age-related macular degeneration and Alzheimer disease
Authors : Eren Çerman, Muhsin Eraslan, Osman Çekiç
Pages : 1004-1009
View : 19 | Download : 6
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :This review highlight the similarities in the pathogenesis between Alzheimer disease and age-related macular degeneration. All studies published between 1990 and 2014 were reviewed to identify the common pathological pathways. Alzheimer disease and age-related macular degeneration share common features such as vitronectin and amyloid-β accumulation, increased oxidative stress, and apolipoprotein and complement activation pathways, which are reviewed as histologic and immunologic common features.Keywords : Age-related macular degeneration, Alzheimer disease, amyloid-β, drusen, senile plaques