- Turkish Journal of Medical Sciences
- Vol: 44 Issue: 6
- Investigation of serum macrophage migration inhibitor factor and monocyte chemotactic protein-1 leve...
Investigation of serum macrophage migration inhibitor factor and monocyte chemotactic protein-1 levels in irritable bowel syndrome
Authors : Feti Tülübaş, Mustafa Oran, Rafet Mete, Filiz Turan, Ahsen Yilmaz, Zeynep Deniz Yildiz, Ahmet Gürel
Pages : 967-971
Doi:10.3906/sag-1302-90
View : 18 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result from immune activation. The aim of this study was to evaluate macrophage migration inhibitory factor (MMIF) and monocyte chemotactic protein-1 (MCP-1) levels in IBS patients. Materials and methods: We enrolled 30 IBS patients and 30 healthy controls. The MMIF and MCP-1 levels of all patients and controls were detected using commercial enzyme-linked immunosorbent assay kits. Results: Serum MMIF and MCP-1 levels were markedly higher in IBS patients than in controls. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts did not differ significantly between groups. Conclusion: These results show that alterations in MMIF and MCP-1 affect the proinflammatory process. They also suggest that MMIF and MCP-1 may play a substantial role in IBS.Keywords : Irritable bowel syndrome, macrophage migration inhibitory factor, monocyte chemotactic protein, inflammation