- Turkish Journal of Medical Sciences
- Vol: 45 Issue: 1
- Stress-responsive factor regulation in patients suffering from type 2 diabetes and myocardial infarc...
Stress-responsive factor regulation in patients suffering from type 2 diabetes and myocardial infarction
Authors : Sobia Mushtaq, Tahir Ali, Farhana Altaf, Muhammad Abdullah, Iram Murtaza
Pages : 148-152
Doi:10.3906/sag-1308-25
View : 12 | Download : 9
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Pro-free radical oxidative stresses, as well as regulatory factors, are believed to be the key players in the development of diabetes and heart-related disorders such as myocardial infarction. The aim of the present study was to highlight the role of oxidative stress-responsive factors (reactive oxygen species [ROS], super oxide dismutase [SOD], and calpain-1) in type 2 diabetes and myocardial infarction. Materials and methods: A total of 100 type 2 diabetes patients with myocardial infarction and 50 normal individuals were selected for this analysis. The levels of ROS and activities of SOD in the serum were determined. Serum calpain-1 expression was checked using western blotting. Results: The serum level of ROS and the expression of calpain-1 were significantly higher while the activity of SOD was significantly lower in diabetic patients with myocardial infraction compared to normal individuals. Conclusion: These findings suggest a possible link between decreased antioxidant (SOD) and increased ROS levels as well as calpain-1 expression, supporting the role of oxidative stress-regulatory factors in diabetes and myocardial infraction.Keywords : Diabetes mellitus, myocardial infraction, super oxide dismutase, reactive oxygen species, calpain-1