- Turkish Journal of Medical Sciences
- Vol: 45 Issue: 1
- Efficacy of entecavir treatment among chronic hepatitis B nucleos(t)ide-naïve and -experienced patie...
Efficacy of entecavir treatment among chronic hepatitis B nucleos(t)ide-naïve and -experienced patients
Authors : Kadir Çağatay Biçer, Alpay Ari, Vecdi Evren Genç, Sibel Özsu Caymaz, Meltem Avci, Fatma Bal
Pages : 99-104
Doi:10.3906/sag-1309-78
View : 13 | Download : 3
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :To evaluate the efficacy of entecavir (ETV) among chronic hepatitis B (CHB) nucleos(t)ide-naïve and -experienced patients in clinical practice. Materials and methods: In this retrospective study 85 CHB patients who had been receiving ETV and who attended our clinic since 2007 were included. Fifty patients were nucleos(t)ide analogue (NA)-naïve. Factors including sex, positive HBeAg, baseline HBV DNA level, baseline alanine aminotransferase level, and prior lamivudine (LAM) resistance were evaluated in terms of their predictive role in treatment response, which was defined as a serum HBV DNA decrease ofKeywords : Chronic hepatitis B virus infection, entecavir, efficacy, predictive factors, viral response, lamivudine resistance