- Turkish Journal of Medical Sciences
- Vol: 29 Issue: 6
- Action of Aspirin on Acetylcholine-Stimulated Tear Secretion in Rats
Action of Aspirin on Acetylcholine-Stimulated Tear Secretion in Rats
Authors : Zerrin Kapicioğlu
Pages : 623-626
View : 7 | Download : 3
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :In this study we investigated the effect of acetylsalicylic acid (ASA) on tear secretion in rats. The animals were anesthetized intraperitoneally (ip) with urethane (1,2g/kg). The treatment was injected subcutaneously (s.c.). Tear samples were collected by folding a 5 mm section of a Schirmer strip over the lower lid margin to absorb tear fluid from the lower conjunctival sac for 5 min. Forty animals were divided into four groups (n=10). Group 1 (control) received 1ml of saline, group 2 received 60mg/kg of ASA, group 3 received 50mg/kg of Acetylcholine (Ach), and group 4 received 60mg/kg of ASA and 30 min later 50mg of Ach. While Ach alone significantly increased tear secretion, ASA reduced it when compared to saline (control) (pKeywords : Aspirin, acetylsalicylic acid, acetylcholine, tear secretion, rat.