- Turkish Journal of Medical Sciences
- Vol: 31 Issue: 2
- Immunohistochemical Expression of C-Erb-B2, Steroid Receptors and Cathepsin-D in Breast Carcinomas: ...
Immunohistochemical Expression of C-Erb-B2, Steroid Receptors and Cathepsin-D in Breast Carcinomas: A Clinicopathologic Trial
Authors : Hatice Elif Peştereli
Pages : 131-136
View : 7 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Aim: We investigated the role of c-erb-B2, hormone receptors and cathepsin D in breast carcinoma progression and their correlation with each other. Methods: Forty-six breast carcinoma patients, operated on in the deparment of surgery and diagnosed in the pathology department, were classified according to their histopathological characteristics; the results of immunostaining with estrogen and progesterone receptors, c-erb-B2 and cathepsin-D were correlated with the stage and the disease-free survival of the patients. Results: Nuclear positivity was observed in 23 (50 %) cases for estrogen receptor and in 16 (34.8 %) cases for progesterone receptor. There was membranous staining with c-erb-B2 in 37 (80.4 %) cases and cytoplasmic staining with cathepsin-D in 44 (95.6 %) cases. Cathepsin-D positivity was significantly related to the axillary lymph node metastases (pKeywords : Breast carcioma, cathepsin-D, c-erb-B2