- Turkish Journal of Medical Sciences
- Vol: 33 Issue: 2
- Lipid Peroxidation, Nitrate and Nitrite Levels in Eclamptic and Intrauterine Growth Retarded Pregnan...
Lipid Peroxidation, Nitrate and Nitrite Levels in Eclamptic and Intrauterine Growth Retarded Pregnancies
Authors : Hatice Paşaoğlu
Pages : 89-93
View : 10 | Download : 2
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :In this study we investigated nitric oxide metabolites nitrate+nitrite and lipid peroxidation product (malonyldialdehyde: MDA) related to the pathogenesis of eclampsia and intrauterine growth retarded (IUGR) pregnancy. Plasma nitrate+nitrite levels were higher in the eclamptic (31.6 ± 16.7 µmol/L p < 0.001) and IUGR (24.3 ± 9.5 µmol/L p < 0.005) groups than in the control group (18.8 ± 6.9 µmol /L). Plasma MDA levels were higher in the eclamptic group (5.5 ± 2.5 nmol/ml (p < 0.05) but not significantly different in the IUGR (3.4 ± 2.4 nmol/ml p > 0.05) group than control group (3.0 ± 1.3 nmol/ml). In addition, the plasma nitrite+nitrate and MDA levels in the eclamptic group were higher than in the IUGR group (p < 0.05). These variations could play different roles in the pathogenesis of eclampsia and IUGR pregnancy.Keywords : Eclampsia, IUGR, nitric oxide, lipid peroxidation