- Turkish Journal of Medical Sciences
- Vol: 41 Issue: 1
- Urginea maritima (L.) Baker (Liliaceae) extract induces more cytotoxicity than standard chemotherape...
Urginea maritima (L.) Baker (Liliaceae) extract induces more cytotoxicity than standard chemotherapeutics in the A549 non-small cell lung cancer (NSCLC) cell line
Authors : Hakan BOZCUK, Mustafa ÖZDOĞAN, Oktay AYKURT, Fatih TOPÇUOĞLU, Hasan ÖZTÜRK, Deniz EKİNCİ, Asuman KARADENİZ, Aylin MUTLU, Durmuş BURGUCU
Pages : 101-108
View : 13 | Download : 2
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Urginea maritima (Um) is a plant native to especially Turkey and the Mediterranean area. In this study, we investigated whether Um extract exerted cytotoxicity on cancer cells. Materials and methods: We made various extracts of Um. These extracts in varying concentrations were added to an A549 NSCLC cell culture, alone or with gemcitabine and/or cisplatin. Growth inhibition was tested by the MTT assay and an Annexin V-FITC apoptosis detection kit Results: The onion Um extract (1 µg/mL) was more cytotoxic than cisplatin (1 µg/mL), gemcitabine (1 nm/mL), and leaf Um extract (1 µg/mL) with P < 0.001, P = 0.097, and P < 0.001, respectively. The efficacy of Um extract was further improved by the addition of an antioxidant cocktail to an IC50 value of 0.02 µg/mL. Conclusion: Um extract has been shown for the first time to be a strong candidate for drug development in solid tumors. Our studies continue to further define the specific antitumor compound(s) in this extract.Keywords : Key words: Urginea maritima, cytotoxicity, apoptosis, MTT, non-small cell lung cancer