- Turkish Journal of Medical Sciences
- Vol: 42 Issue: 6
- The ESR1 gene polymorphisms in patients with coronary artery disease in the southeastern Turkish pop...
The ESR1 gene polymorphisms in patients with coronary artery disease in the southeastern Turkish population
Authors : Abdussemet Hazar, Fuat Dilmeç, Aydemir Koçarslan, Mustafa Göz, Mehmet Salih Aydin, Abbas Heval Demirkol
Pages : 1050-1057
View : 13 | Download : 2
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :The objective of this study was to evaluate the prevalence of the estrogen receptor 1 (ESR1) gene variants and their possible association with coronary artery disease (CAD) in Şanlıurfa province. Materials and methods: We used polymerase chain reaction and restriction enzyme digestion to determine the prevalence of the ESR1 gene (NM001122742.1, GI: 2099): c.454-351 A>G (XbaI A>G) and c.454-397 T>C (PvuII T>C) polymorphisms in 100 healthy individuals and 80 angiographically confirmed CAD patients. Results: The body mass index (28.1 ± 5.4), low-density lipoprotein cholesterol (126.1 ± 42 mg/dL), diabetes (n = 13), and hypertension (n = 39) values of the CAD patients were significantly higher than in the control subjects (26.2 ± 3.9, 106.1 ± 26.3, 2, and 18, respectively) (P < 0.05). No significant differences were observed in the frequencies of both the c.454-351 A>G and c.454-397 T>C genotype of the ESR1 gene in CAD patients compared to healthy individuals (P > 0.05). Conclusion: The ESR1 variants tested in this study were not associated with CAD. Therefore, neither of these 2 variants can be considered as an independent risk factor or a predictor for CAD in the studied Turkish population.Keywords : Key words: Coronary artery disease, estrogen receptor 1 gene, polymorphism, polymerase chain reaction, restriction fragment length polymorphism, single nucleotide polymorphism