- Turkish Journal of Medical Sciences
- Vol: 42 Issue: Sup.2
- Circulating levels of IGF-I and IGFBP-3 in gastric cancer
Circulating levels of IGF-I and IGFBP-3 in gastric cancer
Authors : Konca Altinkaynak, Memet Bilici, Nuri Bakan, Fatih Akçay
Pages : 1458-1462
View : 16 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :To explore the causative mechanism of gastric carcinoma and to investigate the roles of circulating IGF-I and IGFBP-3 in gastric cancer. Materials and methods: Serum IGF-I and IGFBP-3 concentrations were measured using a 2-site coated tube immunoradiometric assay. Results: Serum IGF-I and IGFBP-3 values in gastric cancer patients were significantly lower compared to those in the control group. The difference between serum IGF-I/IGFBP-3 in patients and the control group was not significant. Conclusion: The low serum IGF-I and IGFBP-3 levels detected in patients with gastric cancer could be due to decreased synthesis or increased catabolism of IGF-I or both. It could be suggested that these parameters may be important in the development and prognosis of gastric cancer.Keywords : Key words: Insulin-like growth factors, insulin-like growth factor-1, stage, gastric cancer