- Turkish Journal of Medical Sciences
- Vol: 43 Issue: 1
- The effects of formaldehyde intoxication on the inducible nitric oxide synthase expression and nitri...
The effects of formaldehyde intoxication on the inducible nitric oxide synthase expression and nitric oxide level in the liver tissue of rats
Authors : Ergün UÇMAKLI, Ferah ARMUTCU, Alaattin ÖZTÜRK
Pages : 52-56
Doi:10.3906/sag-1206-58
View : 9 | Download : 2
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :To investigate inductive activity of formaldehyde (FA) on the expression of inducible nitric oxide synthase (iNOS) and level of nitric oxide (NO) in the liver of rats. Materials and methods: Sixteen male Wistar albino rats of the same age (3 months old) were divided into 2 experimental groups, with 8 rats as the control and 8 rats formaldehyde-treated (FAt). The FAt group received intraperitoneal injection of 10 mg/kg FA for 10 days. Activity of iNOS was shown with immunohistochemical stain kits, and the concentration of NO level was measured by spectrophotometric method in the liver tissue. Results: The FAt group had increased iNOS expression and NO levels in liver tissue compared to controls. Conclusion: FA increased iNOS expression and NO production in liver tissue of rats.Keywords : Key words: Formaldehyde, nitric oxide, iNOS, rat liver