- Turkish Journal of Medical Sciences
- Vol: 43 Issue: 4
- Urease inhibitory potential of Zizyphus oxyphylla Edgew. extracts and isolated compounds
Urease inhibitory potential of Zizyphus oxyphylla Edgew. extracts and isolated compounds
Authors : Waqar Ahmad Kaleem, Muhammad Nisar, Mughal Qayum
Pages : 497-500
Doi:10.3906/sag-1208-28
View : 8 | Download : 3
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :To determine the urease inhibitory potential of extracts and isolated compounds from Zizyphus oxyphylla Edgew. Materials and methods: Methanolic extracts and subsequent fractions of Z. oxyphylla stem and 3 isolated compounds from the roots of Z. oxyphylla were obtained through column chromatography and subjected to in vitro urease inhibition. Results: Three fractions (n-hexane, ethyl acetate, and butanol fractions) showed good to excellent activity, while the chloroform fraction showed nonsignificant activity. Amongst the isolated compounds, oxyphylline D (1) was the most active of the 3 isolated cyclopeptide alkaloids, followed by nummularin R (3) and nummularin C (2). Conclusion: Z. oxyphylla has the potential to be used in the treatment of various complications produced by urease enzymes, such as gastric ulcers.Keywords : Key words: Zizyphus oxyphylla, cyclopeptide alkaloids, urease