- Turkish Journal of Chemistry
- Vol: 44 Issue: 2
- Arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the pre...
Arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the preparation of aryl iodide
Authors : Lıa Zaharani, Nader Ghaffarı Khaligh, Zohreh Shahnavaz, Mohd Rafıe Johan
Pages : 535-542
Doi:10.3906/kim-2002-26
View : 12 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :In the current protocol, the arene diazonium saccharin derivatives were initially produced from various substituted aromatic amines; subsequently, these intermediates were treated with a greener organic iodide for the preparation of the aryl iodide. We tried to choose low-cost, commercially available, biodegradable, recoverable, ecofriendly, and safe reagents and solvents. The arene diazonium saccharin intermediates could be stored in the liquid phase into a refrigerator for a long time with no significant loss activity. The outstanding merits of the current protocol a included the partial recovering of saccharin and tetraethylammonium salt, b reduce the use of solvents and the reaction steps due to eliminating separation and purification of intermediates, c good yield of the sterically hindered substrates, and d avoid the generation of heavy metal or corrosive waste.Keywords : Aromatic iodide, one-pot diazotization-iodination, saccharin, waste prevention