- Turkish Journal of Chemistry
- Vol: 43 Issue: 1
- Efficient synthesis and antifungal investigation of nucleosides' quaternary ammonium salt derivative...
Efficient synthesis and antifungal investigation of nucleosides' quaternary ammonium salt derivatives
Authors : Barbara Dmochowska, Lucyna Pellowska-januszek, Justyna Samaszko-fiertek, Rafal Slusarz, Roland Wakiec, Janusz Madaj
Pages : 157-171
View : 6 | Download : 7
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Quaternary ammonium salts are a group of compounds with diverse biological properties, the most important of which are their antiviral, antibacterial, and antifungal activities. The quaternization reactions of 5'-$O$-tosyl derivatives of uridine and thymidine with triethylamine, trimethylamine, 4-($N$,$N$-dimethylamino)pyridine, 2-methylpyridine, and pyridine are described in this article. Two of the synthesized compounds are exceptional because they are first of this type that demonstrate concentration-dependent antifungal in vitro activity against two species of the genus Candida in minimal YNB-SG medium. The experimental results have been extended by adding full atom molecular dynamics simulations and substrates and products energies evaluation.Keywords : Quaternary ammonium salts, uridine-5 extquotesingle-ammonium derivatives, thymidine-5 extquotesingle-ammonium derivatives