- Turkish Journal of Chemistry
- Vol: 43 Issue: 1
- 1,2-Dibromotetrachloroethane: an efficient reagent for many transformations by modified Appel reacti...
1,2-Dibromotetrachloroethane: an efficient reagent for many transformations by modified Appel reaction
Authors : Selçuk Eşsiz, Arif Daştan
Pages : 150-156
View : 6 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :An efficient and facile method has been developed for the synthesis of alkyl bromides from various alcohols under mild conditions using a triphenylphosphine (PPh$_{3})$/1,2-dibromotetrachloroethane (DBTCE) complex in excellent yields and very short time (5 min). This method can also be applied for the transformation of chiral alcohols to their corresponding bromides in very high enantiomeric excess. The PPh$_{3}$/DBTCE complex is also successfully applied to ring-opening reactions of cyclic ethers in mild conditions. Esterification, amidation, and formation of acid anhydrides under very mild experimental conditions are also successfully accomplished by following a modification of the Appel reaction protocol in this work.Keywords : Alkyl bromides, 1, 2-dibromotetrachloroethane, ring-opening reaction, Appel reaction, configuration inversion