- Turkish Journal of Chemistry
- Vol: 43 Issue: 1
- The protective effect of N-acetylcysteine amide against paraquat-induced neurotoxicity
The protective effect of N-acetylcysteine amide against paraquat-induced neurotoxicity
Authors : Burhan Ateş, Nigar Vardi, Hakan Parlakpinar, Merve Gökşin Karaaslan, Ismet Yilmaz, Nuran Ercal
Pages : 39-49
View : 19 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :N-acetylcysteine amide (NACA) is a new antioxidant molecule with powerful radical scavenging properties. The aim of this study was to investigate neuroprotective effects of NACA against paraquat (PQ) toxicity in the midbrains of rats by using motor coordination tests and biochemical and histological analysis. Thirty adult Wistar albino rats were divided into three groups: Group 1: control (n = 10), Group 2: PQ (10 mg/kg) (n = 10), and Group 3: PQ (10 mg/kg) $+$ NACA (100 mg/kg) (n = 10). NACA was administrated intraperitoneally 30 min before PQ injection. Performance was measured for a period of 28 days. The rotarod and accelerod tests were performed prior to and after the experimental period. After the experimental period, rats were sacrificed and midbrain tissues were removed. According to biochemical data, malondialdehyde levels exhibited a significant increase (P $Keywords : Thiol antioxidant, N-acetylcysteine amide, paraquat, neuroprotective, glutathione