- Turkish Journal of Chemistry
- Vol: 42 Issue: 6
- An efficient water-mediated synthetic route for the alkylation of heteroarenes
An efficient water-mediated synthetic route for the alkylation of heteroarenes
Authors : Pinar Seyitdanlioğlu, Essam Hamied Ahmed Hanashalhalshahaby, Canan Ünaleroğlu
Pages : 1598-1610
View : 8 | Download : 3
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :An efficient synthetic route has been described for the alkylation of 1$H$-indole, 1$H$-benzimidazole, and 1$H$-benzotriazole. This approach features the alkylation of heteroaromatics through in situ generated enones from ketonic Mannich bases under metal-free conditions. A series of alkylated heteroaromatics have been synthesized via the K10 catalyzed alkylation reactions of these heteroaromatics with a variety of ketonic Mannich bases. Environmentally benign K10 catalyst, water-mediated mild reaction conditions, and the efficient synthesis of alkylated products are the advantages of this alkylation method.Keywords : Mannich base, alkylation reaction of 1$H$-indole 1$H$-benzimidazole and 1$H$-benzotriazole, K10, environmentally friendly synthesis