- Turkish Journal of Chemistry
- Vol: 42 Issue: 1
- Biological study on novel coumarinyl 1,3,4-oxadiazoles
Biological study on novel coumarinyl 1,3,4-oxadiazoles
Authors : Maja MOLNAR, Ana AMIC, Valentina PAVIC, Tihomir KOVAC, Marija KOVAC, Elizabeta HAS-SCHÖN
Pages : 146-157
View : 5 | Download : 3
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Coumarinyl 1,3,4-oxadiazoles were synthesized from Schiff bases and acetic anhydride. All compounds were characterized by melting points and their structures conrmed by mass and $^{1}$H and $^{13}$C NMR spectrometry. These novel coumarinyl derivatives were subjected to antibacterial, antifungal, anta atoxigenic, and antioxidant activity. Their activity varied depending on their structure, where 2-(3-acetyl-5-(((4-methyl-2-oxo-2H-chromen-7-yl)oxy)methyl)- 2,3-dihydro-1,3,4-oxadiazol-2-yl)-1,4-phenylene diacetate showed signicant antioxidant and antibacterial activity on B. subtilis. 4-(3-Acetyl-5-(((4-methyl-2-oxo-2H-chromen-7-yl)oxy)methyl)-2,3-dihydro-1,3,4-oxadiazol-2-yl)-1,2-phenylene diacetate was found to possess excellent antifungal and antia atoxigenic activity.Keywords : Coumarin, 1, 3, 4-oxadiazole, antibacterial, antifungal, antimycotoxigenic activity