- Turkish Journal of Chemistry
- Vol: 42 Issue: 1
- Synthesis of benzaldehyde by Swern oxidation of benzyl alcohol in a continuous flow microreactor sys...
Synthesis of benzaldehyde by Swern oxidation of benzyl alcohol in a continuous flow microreactor system
Authors : Lin Zhu, Xiaohui Xu, Fuping Zheng
Pages : 75-85
View : 7 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Preparation of benzaldehyde by Swern oxidation of benzyl alcohol was carried out in a continuous flow microreactor system. Dimethyl sulfoxide (Me2SO) was used as oxidizing agent and oxalyl chloride or p-toluenesulfonyl (p-TsCl) chloride was used as the activating agent. Benzyl alcohol was oxidized to benzaldehyde by the Me2SO-activating agent mixture in the continuous flow microreactor system. The optimized reaction conditions of the Swern oxidation were as follows: oxalyl chloride was used as the activating agent; the mole ratio of Me2SO, oxalyl chloride, and benzyl alcohol was 4:2:1; the ow rate of Me2SO was 1.5 mL/min; the reaction temperature was 15 ℃; length of delay loop was 1.5 m; a Caterpillar Split-Recombine Micro Mixer was used; and all of the experiments were completed at atmospheric pressure. The yield of benzaldehyde can reach 84.7% with selectivity of 98.5%. Due to the small reactor volume and short residence times, the Swern oxidation of benzyl alcohol in a continuous flow microreactor system can be operated at nearly room temperature (5–19 ℃) instead of –70 ℃ in a batch reaction, with residence time of reactants in microreactors in milliseconds instead of several hours in a batch reaction.Keywords : Swern oxidation, microreactor, benzaldehyde, benzyl alcohol