- Turkish Journal of Chemistry
- Vol: 42 Issue: 1
- Simultaneous determination of azithromycin and levo oxacin in pharmaceuticals by charge transfer com...
Simultaneous determination of azithromycin and levo oxacin in pharmaceuticals by charge transfer complexation with alizarin red S using an absorption-factor method
Authors : Vijay D. Chavada, Nejal M. Bhatt, Mallika Sanyal, Pranav S. Shrivastav
Pages : 36-49
View : 8 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :A new approach based on a selective charge transfer reaction with alizarin red S is described for the simultaneous determination of azithromycin and levo oxacin in their binary mixtures using an absorption-factor spectrophotometric method. Native absorbance was used for the determination for levo oxacin, while a charge transfer complexation of alizarin red S served as the basis for the quantitation of azithromycin. The reaction of azithromycin with alizarin red S was possible in methanol under neutral conditions within 15 min at 25 ℃. The conditions were suitably optimized for selective complexation of azithromycin with minimal interference from levo oxacin. The calibration curve was linear over the concentration range of 4.0–20Keywords : Absorption-factor method, azithromycin, levo oxacin, alizarin red S, charge transfer complexation