- Turkish Journal of Chemistry
- Vol: 41 Issue: 3
- Synthesis of novel derivatives of chromenone bearing an $N$-carbamothioyl moiety as soybean 15-LOX i...
Synthesis of novel derivatives of chromenone bearing an $N$-carbamothioyl moiety as soybean 15-LOX inhibitors
Authors : Robabeh Kaviani, Mina Saeedi, Mohammad Mahdavi, Hamind Nadri, Alireza Moradi, Abbas Shafiee, Tahmineh Akbarzadeh
Pages : 335-344
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Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Novel derivatives of chromenone bearing an $N$-carbamothioyl moiety were synthesized and evaluated for their soybean 15-LOX inhibitory activity. Synthesis of the target compounds was started from 7-hydroxy-2$H$-chromen-2-one. It was reacted with 1-fluoro-2(4)-nitrobenzene to obtain the corresponding nitrophenoxy-chromenone derivative. Reduction of the nitro group was achieved in the presence of Zn/NH$_{4}$Cl and reaction of the latter compound with in situ prepared benzoyl isothiocyanate led to the formation of the title compounds. All compounds were characterized and tested against soybean 15-LOX. Among them, 4-methyl-$N$-((4-((2-oxo-2$H$-chromen-7-yl)oxy)phenyl)carbamothioyl)benzamide (7l) showed the best activity as potent as the reference drug, quercetin.Keywords : Chromenone, nitro compounds, $N$-carbamothioyl, soybean 15-LOX