- Turkish Journal of Chemistry
- Vol: 41 Issue: 1
- Synthesis and cytotoxicity of novel thioxo-quinazolino[3,4-$a$]quinazolinones
Synthesis and cytotoxicity of novel thioxo-quinazolino[3,4-$a$]quinazolinones
Authors : Negar Mohammadhosseini, Mina Saeedi, Shahram Moradi, Mohammad Mahdavi, Omidreza Firuzi, Alireza Foroumadi, Abbas Shafiee
Pages : 125-134
View : 7 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Various thioxo-quinazolino[3,4-$a$]quinazolinones were prepared and evaluated for their cytotoxicity in MOLT-4 (lymphoblastic leukemia) and MCF-7 (breast adenocarcinoma) cell lines. Synthesis of the target compounds was started from isatoic anhydride. Successive reaction of isatoic anhydride with benzylamine and 2-nitrobenzaldehyde, reduction of the nitro group, and reaction with CS$_{2}$ gave 12-benzyl-6-thioxo-6,7,11b,12-tetrahydro-13$H$-quinazolino[3,4-$a$]quinazolin-13-one. The latter compound reacted with various 2-chloro-$N$-substituted acetamides to afford the corresponding fused quinazolinone derivatives.Keywords : Quinazolinones, cytotoxicity, thioxo-quinazolino[3, 4-$a$]quinazoline, 2-nitrobenzaldehyde