- Turkish Journal of Chemistry
- Vol: 40 Issue: 4
- Synthesis, reaction, and evaluation of the anticancer activity of 6,7,8,9-tetrahydro-5$H$-cyclohepta...
Synthesis, reaction, and evaluation of the anticancer activity of 6,7,8,9-tetrahydro-5$H$-cyclohepta[4,5]selenopheno[2,3-$d$]pyrimidine derivatives
Authors : Kadir Doğanay, Ünzile Keleştemur, Sevgi Balcioğlu, Burhan Ateş, Aliye Altundaş
Pages : 631-640
View : 12 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :The cyclocondensation of 2-amino-5,6,7,8-tetrahydro-4$H$-cyclohepta[$b$] selenophene-3-carbonitrile (1) with formic acid and formamide gave the selenophenopyrimidine 15 and selenophenopyrimidone 6 derivatives. The reaction of 6 with phosphorus oxychloride produced 4-chloro-6,7,8,9-tetrahydro-5$H$-cyclohepta[4,5] seleno[2,3-$d$]pyrimidine (12), the key compound for our nucleophilic substitution reactions. The hydrazinoselenophenopyrimidine 19 obtained from the reaction of 12 with hydrazine hydrate was converted to its tetrazoloselenophenopyrimidine 21 and triazoloselenophenopyrimidine 26 derivatives. Moreover, the chloropyrimidine derivative was reacted with pyrrolidine and morpholine to afford 4-(1-pyrrolidinyl)-6,7,8,9-tetrahydro-5$H$-cylohepta[4,5]selenopheno[2,3-$d$]pyrimidine (27) and 4-(6,7,8,9-tetrahydro-5$H$-cyclohepta[4,5]selenopheno[2,3-$d$]pirimidin-4-yl)morpholine (28). Anticancer activities of the synthesized compounds were investigated against the MCF-7 breast cancer cell line and the IC$_{50}$ values of these compounds were in the range of 70.86--250.06 $\mu $M.Keywords : Selenophene, selenophenopyrimidine, organoselenium, anticancer activity