- Turkish Journal of Chemistry
- Vol: 40 Issue: 2
- Synthetic approaches towards the synthesis of beta-blockers (betaxolol, metoprolol, sotalol, and tim...
Synthetic approaches towards the synthesis of beta-blockers (betaxolol, metoprolol, sotalol, and timolol)
Authors : Furqan Ahmad Saddique, Ameer Fawad Zahoor, Muhammmad Yousaf, Muhammmad Irfan, Matloob Ahmad, Asim Mansha, Zulfiqar Ali Khan, Syed Ali Raza Naqvi
Pages : 193-224
View : 9 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Numerous efficient synthetic methodologies have been elaborated for the synthesis of $\beta $-blockers since the introduction of propranolol (a beta-blocker) in 1968. In this review, focus is placed on the more concise asymmetric and bioenzymatic synthetic approaches attempted towards the synthesis of beta-blockers (betaxolol, metoprolol, sotalol, and timolol).Keywords : Beta-blockers, cardiovascular activity, antiglaucoma agent, biotransformations