- Turkish Journal of Chemistry
- Vol: 40 Issue: 1
- Synthetic protocols on 6$H$-benzo[$c$]chromen-6-ones: a review
Synthetic protocols on 6$H$-benzo[$c$]chromen-6-ones: a review
Authors : Ofentse Mazimba
Pages : 1-27
View : 9 | Download : 6
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :6$H$-Benzo[$c$]chromen-6-ones serve as core structures of secondary metabolites and are of considerable pharmacological importance. Natural sources produce limited quantities, hence the need for synthetic procedures for 6$H$-benzo[$c$]chromen-6-ones, which are herein reviewed. The literature describes protocols such as the Suzuki coupling reactions for the synthesis of biaryl, which then undergoes lactonization, reactions of 3-formylcoumarin (chromenones) with 1,3-bis(silylenol ethers), radical mediated cyclization of arylbenzoates, metal or base catalyzed cyclization of phenyl-2-halobenzoates and 2-halobenzyloxyphenols, and benzoic acid coupling with benzoquinone using electrophilic metal-based catalyst. The efficient and simple procedures are those involving the reactions of Michael acceptor (chromenones and chalcones) with 1,3- and 1,5-dicarbonyl compounds.Keywords : 6$H$-Benzo[$c$]chromen-6-ones, benzopyranone, biaryls, Suzuki coupling, Michael addition, lactonization