- Turkish Journal of Chemistry
- Vol: 39 Issue: 2
- Synthesis and biological evaluation of new pyridines containing imidazole moiety as antimicrobial an...
Synthesis and biological evaluation of new pyridines containing imidazole moiety as antimicrobial and anticancer agents
Authors : Ikhlass Abbas, Sobhi Gomha, Mahmoud Elaasser, Mohammed Bauomi
Pages : 334-0
Doi:10.3906/kim-1410-25
View : 9 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :The synthesis of a novel series of pyridine and bipyridine derivatives is described via one-pot multicomponent reaction of 5-acetylimidazole, malonitrile (or ethylcyanoacetate or diethylmalonate), substituted benzaldehyde (or terephthaldehyde), and ammonium acetate in good yields. The structures of all the new compounds were elucidated on the basis of elemental analysis and spectral data. The antimicrobial activities of the synthesized compounds were screened and the results showed that most of such compounds exhibit considerable activities. Furthermore, some of the newly synthesized compounds were screened for their anticancer activity against human breast cell line (MCF-7) and liver carcinoma cell line (HEPG2) in comparison to doxorubicin. Most of the tested compounds exhibited promising activity.Keywords : 5-Acetylimidazole, cyanopyridone, bipyridine, multicomponent reactions, anticancer activity