- Turkish Journal of Chemistry
- Vol: 39 Issue: 2
- Regiospecific one-pot, combinatorial synthesis of new substituted pyrimido[4,5-c]pyridazines as pote...
Regiospecific one-pot, combinatorial synthesis of new substituted pyrimido[4,5-c]pyridazines as potential monoamine oxidase inhibitors
Authors : Mehdi Rimaz, Paria Pourhossein, Behzad Khalili
Pages : 244-0
Doi:10.3906/kim-1408-32
View : 18 | Download : 6
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :New 3-aryl-6-methylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and 3-aryl-6-ethyl-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazin-5(6H)-ones were efficiently synthesized via a regiospecific one-pot reaction of N-methylbarbituric acid and N-ethyl-2-thiobarbituric acid with various arylglyoxal monohydrates in the presence of hydrazine dihydrochloride in ethanol at 50 °C. The target compounds were obtained in high yields and were regioisomerically pure after recrystallization. These new heterocycles may act as potential MAO_{B} inhibitors.Keywords : Pyrimido[4, 5-c]pyridazine, regiospecific, arylglyoxal, N-methylbarbituric acid, N-ethyl-2-thiobarbituric acid