- Turkish Journal of Chemistry
- Vol: 38 Issue: 4
- Aqueous DABCO, an efficient medium for rapid organocatalyzed Knoevenagel condensation and the Gewald...
Aqueous DABCO, an efficient medium for rapid organocatalyzed Knoevenagel condensation and the Gewald reaction
Authors : Mohammad Saeed Abaee, Somayeh Cheraghi
Pages : 650-660
Doi:10.3906/kim-1309-38
View : 10 | Download : 6
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :In the presence of water and 1,4-diazabicyclo[2.2.2]octane, several aldehydes and cyclic ketones underwent efficient Knoevenagel condensation with malononitrile and ethyl cyanoacetate to produce the respective a.b-unsaturated systems within fairly short time periods. As a result, high yields of conjugated products were easily obtained. Products could be engaged in a Gewald reaction, either stepwise or in situ, to produce efficiently their respective 2-aminothiophenes within 4--7 h.Keywords : Knoevenagel condensation, Gewald reaction, organocatalysis, aqueous conditions, amine