- Turkish Journal of Chemistry
- Vol: 39 Issue: 1
- Synthesis of tetrahydropyrimidinium salts and their in situ catalytic activities towards the Buchwal...
Synthesis of tetrahydropyrimidinium salts and their in situ catalytic activities towards the Buchwald--Hartwig amination reaction under microwave irradiation
Authors : Liangru Yang, Huanyu Bian, Wenpeng Mai, Pu Mao, Yongmei Xiao, Dong Wei, Lingbo Qu
Pages : 121-129
Doi:10.3906/kim-1404-67
View : 7 | Download : 3
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :A series of asymmetrical substituted tetrahydropyrimidinium salts and different kinds of bridged bis-tetrahydropyrimidinium salts were prepared through the quaterization of tetrahydropyrimidine or the dehydrogenation of hexahydropyrimidine. They were characterized and used as NHC precursors in the palladium catalyzed Buchwald--Hartwig amination reaction. The in situ formed catalytic system Pd(OAc)2/tetrahydropyrimidinium and tBuOK catalyzed the amination of heteroaryl halides and heterocyclic amines effectively, producing the heterocyclic amine functionalized heteroaryl derivatives in high yields.Keywords : Tetrahydropyrimidinium salt, Buchwald--Hartwig amination, microwave irradiation, palladium catalysis, N-heterocyclic carbene